2024
Mechanism of 2′-fucosyllactose degradation by human-associated Akkermansia
L Padilla, AD Fricker, E Luna, B Choudhury, ER Hughes, ME Panzetta, ...
Journal of Bacteriology, e00334-23
RJ Bastidas, M Kędzior, RK Davidson, SC Walsh, L Dolat, BS Sixt, ...
eLife 12
2023
RJ Bastidas, RH Valdivia
Current Opinion in Microbiology 74, 102330
LE Davey, PN Malkus, M Villa, L Dolat, ZC Holmes, J Letourneau, ...
Nature Microbiology, 1-18
K Meier, LH Jachmann, G Türköz, MR Babu Sait, L Pérez, O Kepp, ...
Mbio 14 (4), e03190-22
2022
L Dolat, VK Carpenter, YS Chen, M Suzuki, EP Smith, O Kuddar, ...
Cell Host & Microbe 30 (12), 1685-1700. E10
SC Walsh, JR Reitano, MS Dickinson, M Kutsch, D Hernandez, ...
Cell Host & Microbe 30 (12), 1671-1684. e9
2021
Genotypic and phenotypic diversity among human isolates of Akkermansia muciniphila
B Becken, L Davey, DR Middleton, KD Mueller, A Sharma, ZC Holmes, ...
Mbio 12 (3), 10.1128/mbio. 00478-21
I Yanatori, K Miura, YS Chen, RH Valdivia, F Kishi
Journal of Bacteriology 203 (11), 10.1128/jb. 00511-20
An endometrial organoid model of interactions between Chlamydia and epithelial and immune cells
L Dolat, RH Valdivia
Journal of cell science 134 (5), jcs252403
2019
A renewed tool kit to explore Chlamydia pathogenesis: from molecular genetics to new infection models
L Dolat, RH Valdivia
F1000Research 8
Ptr/CTL0175 is required for the efficient recovery of Chlamydia trachomatis from stress induced by gamma-interferon
ME Panzetta, AL Luján, RJ Bastidas, MT Damiani, RH Valdivia, HA Saka
Frontiers in Microbiology 10, 756
Chlamydia trachomatis fails to protect its growth niche against pro-apoptotic insults
BS Sixt, C Núñez-Otero, O Kepp, RH Valdivia, G Kroemer
Cell Death & Differentiation 26 (8), 1485
The Expanding Molecular Genetics Tool Kit in Chlamydia
RH Valdivia, RJ Bastidas
Journal of Bacteriology 200 (24), e00590-18
2018
A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation
JN Pruneda, RJ Bastidas, E Bertsoulaki, KN Swatek, B Santhanam, …
Nature Microbiology 3 (12), 1377
An atlas of genetic variation linking pathogen-induced cellular traits to human disease
L Wang, KJ Pittman, JR Barker, RE Salinas, IB Stanaway, GD Williams, …
Cell Host & Microbe 24 (2), 308-323. e6
Site-specific glycosylation regulates the form and function of the intermediate filament cytoskeleton
HJ Tarbet, L Dolat, TJ Smith, BM Condon, ET O’Brien III, RH Valdivia, …
Elife 7, e31807
Chlamydia trachomatis fails to protect its growth niche against pro-apoptotic insults
BS Sixt, C Núñez-Otero, O Kepp, RH Valdivia, G Kroemer
Cell Death & Differentiation 26 (8), 1485
2017
The effector TepP mediates recruitment and activation of phosphoinositide 3-kinase on early Chlamydia trachomatis vacuoles
V Carpenter, YS Chen, L Dolat, RH Valdivia
MSphere 2 (4), e00207-17
Chlamydia trachomatis’ struggle to keep its host alive
BS Sixt, RH Valdivia, G Kroemer
Microbial Cell 4 (3), 101
2016
Genomic sequencing-based mutational enrichment analysis identifies motility genes in a genetically intractable gut microbe
S Bae, O Mueller, S Wong, JF Rawls, RH Valdivia
Proceedings of the National Academy of Sciences 113 (49), 14127-14132
Molecular Genetic Analysis of Chlamydia Species
BS Sixt, RH Valdivia
Annual Review of Microbiology 70, 179-198
Emancipating Chlamydia: advances in the genetic manipulation of a recalcitrant intracellular pathogen
RJ Bastidas, RH Valdivia
Microbiol. Mol. Biol. Rev. 80 (2), 411-427
Chlamydia Cell biology of the chlamydial inclusion
M Kokes, RH Valdivia
Intracellular Pathogens I: Chlamydiales, 170-191
2015
Differential translocation of host cellular materials into the Chlamydia trachomatis inclusion lumen during chemical fixation
M Kokes, RH Valdivia
PloS one 10 (10), e0139153
Global mapping of the Inc-human interactome reveals that retromer restricts Chlamydia infection
KM Mirrashidi, CA Elwell, E Verschueren, JR Johnson, A Frando, …
Cell Host & Microbe 18 (1), 109-121
Integrating chemical mutagenesis and whole-genome sequencing as a platform for forward and reverse genetic analysis of Chlamydia
M Kokes, JD Dunn, JA Granek, BD Nguyen, JR Barker, RH Valdivia, …
Cell Host & Microbe 17 (5), 716-725
Chlamydia trachomatis infection leads to defined alterations to the lipid droplet proteome in epithelial cells
HA Saka, JW Thompson, YS Chen, LG Dubois, JT Haas, A Moseley, …
PloS one 10 (4), e0124630
2014
A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis
P Engström, KS Krishnan, BD Ngyuen, E Chorell, J Normark, J Silver, …
MBio 6 (1), e02304-14
Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches
EA Snavely, M Kokes, JD Dunn, HA Saka, BD Nguyen, RJ Bastidas, …
Pathogens and Disease 71 (3), 336-351
The Chlamydia trachomatis type III secretion chaperone Slc1 engages multiple early effectors, including TepP, a tyrosine-phosphorylated protein required...
YS Chen, RJ Bastidas, HA Saka, VK Carpenter, KL Richards, GV Plano, …
PLoS pathogens 10 (2), e1003954
2013
The Chlamydia trachomatis inclusion membrane protein CpoS counteracts STING-mediated cellular surveillance and suicide programs
BS Sixt, RJ Bastidas, R Finethy, RM Baxter, VK Carpenter, G Kroemer, …
Cell Host & Microbe 21 (1), 113-121
Mutations in hemG mediate resistance to salicylidene acylhydrazides, demonstrating a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity
P Engström, BD Nguyen, J Normark, I Nilsson, RJ Bastidas, Å Gylfe, …
Journal of Bacteriology 195 (18), 4221-4230
STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection
JR Barker, BJ Koestler, VK Carpenter, DL Burdette, CM Waters, RE Vance, …
MBio 4 (3), e00018-13
Chlamydial intracellular survival strategies
RJ Bastidas, CA Elwell, JN Engel, RH Valdivia
Cold Spring Harbor Perspectives in Medicine 3 (5), a010256
2012
Emerging roles for lipid droplets in immunity and host-pathogen interactions
HA Saka, R Valdivia
Annual Review of Cell and Developmental Biology 28, 411-437
Virulence determinants in the obligate intracellular pathogen Chlamydia trachomatis revealed by forward genetic approaches
BD Nguyen, RH Valdivia
Proceedings of the National Academy of Sciences 109 (4), 1263-1268
A New Dawn for Chlamydia Research-These important and challenging pathogens are finally yielding to modern analytic techniques
D Rockey, R Valdivia
Microbe 7 (9), 393
2011
Quantitative proteomics reveals metabolic and pathogenic properties of Chlamydia trachomatis developmental forms
HA Saka, JW Thompson, YS Chen, Y Kumar, LG Dubois, MA Moseley, …
Molecular Microbiology 82 (5), 1185-1203
The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence
I Jorgensen, MM Bednar, V Amin, BK Davis, JPY Ting, DG McCafferty, …
Cell Host & Microbe 10 (1), 21-32
Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis
BD Nguyen, D Cunningham, X Liang, X Chen, EJ Toone, CRH Raetz, …
Proceedings of the National Academy of Sciences 108 (25), 10284-10289
2010
cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis
MJ Vignola, DF Kashatus, GA Taylor, CM Counter, RH Valdivia
Journal of Biological Chemistry 285 (28), 21625-21635
Acquisition of nutrients by Chlamydiae: unique challenges of living in an intracellular compartment
HA Saka, RH Valdivia
Current Opinion in Microbiology 13 (1), 4-10
2009
New insights into Chlamydia intracellular survival mechanisms
JL Cocchiaro, RH Valdivia
Cellular Microbiology 11 (11), 1571-1578
The Chlamydia type III secretion system C-ring engages a chaperone-effector protein complex
KE Spaeth, YS Chen, RH Valdivia
PLoS pathogens 5 (9), e1000579
Leading a sheltered life: intracellular pathogens and maintenance of vacuolar compartments
Y Kumar, RH Valdivia
Cell Host & Microbe 5 (6), 593-601
2008
Reorganization of the host cytoskeleton by the intracellular pathogen Chlamydia trachomatis
Y Kumar, RH Valdivia
Communicative & Integrative Biology 1 (2), 175-177
Pmp-like proteins Pls1 and Pls2 are secreted into the lumen of the Chlamydia trachomatis inclusion
I Jorgensen, RH Valdivia
Infection and Immunity 76 (9), 3940-3950
Actin and intermediate filaments stabilize the Chlamydia trachomatis vacuole by forming dynamic structural scaffolds
Y Kumar, RH Valdivia
Cell Host & Microbe 4 (2), 159-169
Cytoplasmic lipid droplets are translocated into the lumen of the Chlamydia trachomatis parasitophorous vacuole
JL Cocchiaro, Y Kumar, ER Fischer, T Hackstadt, RH Valdivia
Proceedings of the National Academy of Sciences 105 (27), 9379-9384
Chlamydia effector proteins and new insights into chlamydial cellular microbiology
RH Valdivia
Current Opinion in Microbiology 11 (1), 53-59
2007
Identification of host-induced pathogen genes by differential fluorescence induction reporter systems
D Bumann, RH Valdivia
Nature Protocols 2 (4), 770
2006
The obligate intracellular pathogen Chlamydia trachomatis targets host lipid droplets
Y Kumar, J Cocchiaro, RH Valdivia
Current Biology 16 (16), 1646-1651
Multifunctional analysis of Chlamydia‐specific genes in a yeast expression system
JL Sisko, K Spaeth, Y Kumar, RH Valdivia
Molecular Microbiology 60 (1), 51-66
2004
Modeling the function of bacterial virulence factors in Saccharomyces cerevisiae
RH Valdivia
Eukaryotic Cell 3 (4), 827-834